What could result from excessive doses of Flumazenil?

Flumazenil is a benzodiazepine receptor antagonist, primarily used to reverse the effects of benzodiazepines in cases of sedation or overdose. Administering excessive doses of Flumazenil can lead to seizure activity due to its capacity to reverse the central nervous system (CNS) depressant effects of benzodiazepines.

Benzodiazepines exert their effect by enhancing the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the CNS, providing sedative and anxiolytic effects. When Flumazenil is used excessively, it can lead to rapid unopposed excitatory activity in the CNS, potentially resulting in seizures, especially in individuals who have developed a dependence on benzodiazepines or in cases where the overdose includes multiple substances.

When considering the other options, while increased sedation from Flumazenil would be counterintuitive since it works to counteract sedation, respiratory failure and hypotension are not direct consequences of excess Flumazenil. Excessive doses of Flumazenil primarily disrupt the balance between inhibition and excitation in the brain, leading to seizures rather than respiratory depression or hypotension. This makes seizure activity the most relevant and significant risk associated with excessive doses of Fl