What happens to the glomerular filtration rate in older adults?

In older adults, the glomerular filtration rate (GFR) typically decreases due to a combination of age-related physiological changes and a decline in kidney function. As individuals age, there is a natural reduction in the number of functional nephrons, which are the filtering units of the kidney. This decline can be exacerbated by the presence of chronic conditions such as hypertension and diabetes, which can further impair renal function. The decrease in GFR leads to a reduced ability of the kidneys to filter blood, which can result in alterations in fluid and electrolyte balance, as well as the metabolism of medications and waste products. Therefore, understanding that GFR decreases in older adults is crucial for proper management of their healthcare needs, particularly in pharmacology and renal health.