What is one of the adverse effects related to opioid use?

Pruritus, or itching, is indeed considered an adverse effect related to opioid use. This side effect is particularly notable because it can occur due to the way opioids interact with the opioid receptors in the body, which can stimulate histamine release. This histamine release may lead to itching sensations, especially in response to certain types of opioids.

Understanding this effect is important for healthcare providers, as they need to monitor patients for this and address it appropriately, especially if it becomes bothersome enough to impact the patient's comfort or compliance with their medication regimen.

In the context of the other options, hypotension and excessive sedation can also be adverse effects of opioids, but pruritus is uniquely linked to the histaminergic response. Dry mouth is a common side effect but is less frequently categorized as a serious adverse effect compared to the more systemic impacts of hypotension and sedation. Therefore, pruritus stands out as a significant consideration during opioid therapy, warranting appropriate management and patient education.