What is the maximum total dose of Meperidine for nursing administration in one hour?

The maximum total dose of Meperidine for nursing administration in one hour is 100mg. This guideline is based on safety protocols and the pharmacological profile of Meperidine, which is an opioid analgesic. Administering a total dose exceeding 100mg in one hour increases the risk of adverse effects, including respiratory depression, sedation, and potential for opioid toxicity, particularly in sensitive populations such as the elderly or those with renal impairment.

Understanding the pharmacodynamics of Meperidine is critical, as it has a short half-life and a unique metabolite, normeperidine, that can accumulate and lead to seizures if high doses are used over time. Therefore, clinical practice guidelines establish the 100mg limit to balance effective pain management while minimizing risks to patient safety.