What side effect may occur after repeated administration of Chloral Hydrate in neonates?

Chloral hydrate can lead to metabolic acidosis when administered repeatedly in neonates. This side effect arises primarily due to the metabolism of chloral hydrate itself and the potential for accumulation of its metabolites, which can interfere with normal acid-base balance in the body. In neonates, their immature renal function and limited capacity to handle acid-base changes heighten the risk of developing metabolic acidosis after repeated dosages.

Neonates may also have a different metabolic capacity compared to older children and adults, which can lead to a higher likelihood of adverse effects, including the development of acidosis. Monitoring these patients closely during sedation is crucial to ensure timely identification and management of any such metabolic derangements.